Description
pAAV2-SIG
Adeno-associated Viral Vector (AAV) capsid AAV2-SIG in AAV2Rep expression construct.
Introduction
The peptide SIGYPLP, which targets endothelial cells (EC), into position I-587 of AAV capsids. SIGYPLP-modified AAV (AAVsig) showed enhanced transduction of human EC compared with AAV with a wild-type capsid (AAVwt), a phenotype independent of heparan sulphate proteoglycan (HSPG) binding.
Publication
DOI：10.1006/mthe.2001.0424
Sequence information
Insertion SIGYPLP between 587 and 588
Amino Acid Sequence
MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDR
QLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQ
QPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTST
RTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQN
DGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTF
SYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNN
NSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRTTNPVATEQYGSVSTN
LQRGNSIGYPLPRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPST
TFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL*
- If you are interested in our products, please click on the ‘Add to WishList’ button below;
- Please send your wishlist for details to info@nikebio.com to get in touch with us；
pAAV2-SIG
$1,500.00 – $3,000.00
Related products
-
pAAV-ΔIV-NGR
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAVhum.8
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAV-PAL1D
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAV S3
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page
