pAAVpo2.1
AAV packaging plasmid expressing AAV2 Rep protein and AAVpo2.1 capsid protein
AAVpo2.1 targeted the heart, kidney and muscle, AAVpo5 performed poorly but was able to transduce muscle fibers when injected intramuscularly
Bello, A., et al., Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice. Scientific Reports, 2014. 4(1).
>pAAVpo2.1
VLPGYNYLGPFNGLDKGEPVNRADAVAREHDISYNEQLQAGDNPYLKYNHADAEFQEKLKDDTSFGGNLGKAIFQAKKRVLEPFGLVEAPVKTAPAKKRPIEKSPAEPSSSKGIGKAGQQPARKRLNFGQTGDTDSAADPQPLGEPPAAPSGLGTGTMASGSGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSQSGANNDNHYFGYST
PWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQTDGTKTIANNLTSTVQVFADSEYQLPYVLGSAHQGCFPPFPADVFMVPQYGYLTLNNGSQAMGRSSFY
CLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSKTNGGLGFSQAGPNSMRDQSRNWLPGPCFRQQRISTVPTQNNNGDFSWTGATKYHLNGRNSAM
NPGPAMASHKDDEHRFFPQNGVLIFGKQGADKTNAILEKVIVTDEEEIRTTNPVATEEYGFVATNLQSSAETAETERVNAQGILPGMVWQDRDVYLQGPIWAKIPHTDGHFRPSPL
MGGFGLKHPPPQILIKNTPVPSNPPETFNPEKLNSFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYNKSVNVEFTVDNNGVYSEPRTIGTRYLTRNL
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