pAAV.KK04
AAV packaging plasmid expressing AAV2 Rep protein and AAV.KK04 capsid protein
The novel variant rAAV.KK04 showed the most promise for efficient gene delivery to human cardiomyocytes.
Kok, C.Y., et al., Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes. Molecular Therapy – Methods & Clinical Development, 2023. 30: p. 459-473.
>pAAV.KK04
MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPGKKRPVEPSPQRSPDSSTGIGKKGQQPARKRLNFGQTGDSESVPDPQPLGEPPAAPSGVGTNTMAIGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQAGTSNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKKRSNKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVIQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFQESYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNSTQGSTGTQGTQQLLFSQAGPANMSAQAKNWLPGPCYRQQRLSKTANDNNNSNFPWTAASKYHLNGRDSLVNPGPAMASHKDDEEKFFPMHGNLIFGKEGTTASNAELDNVMITDEEEIRTTNPVATEQYGTVANNLQSSNTAPTTRTVNDQGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQIMIKNTPVPANPPTTFSPAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL*
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