Description
pAAV 1.9-3
Adeno-associated Viral Vector (AAV) capsid AAV 1.9-3 in AAV2Rep expression construct.
Introduction
rAAV1.9-3 has a genetically engineered AAV1 capsid with amino acids 445–568 being replaced with those of
AAV9, and has been identified as a variant exhibiting significantly impaired infectivity and delayed blood clearance when infused into mice.
Publication
DOI：10.1142/S1568558610000197.
Sequence information
rAAV1.9-3 carries an AAV1 and AAV9 hybrid capsid in which amino acids 1–454, 455–567 and 568–736 are derived from AAV1, AAV9 and
AAV1, respectively.
Amino Acid Sequence
MAADGYLPDWLEDNLSEGIREWWDLKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQL
KAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPGKKRPVEQSPQEPDSSSGIGKTGQQPAKK
RLNFGQTGDSESVPDPQPLGEPPATPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYN
NHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTST
VQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEEVPFHSSYAHS
QSLDRLMNPLIDQYLYYLNRTQNQSGGQNQQTLKFSVAGPSNMAVQGRNYIPGPSYRQQRVSTTVTQNNNSEFAWPGASSWALNG
RNSLMNPGPAMASHKEGEDRFFPLSGSLIFGKQGTGRDNVDADKVMITNEEEIKATNPVATERFGTVAVNFQSSSTDPATGDVHAMG
ALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKNPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQ
KENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL*
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pAAV 1.9-3
$1,500.00 – $3,000.00
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