AAV Capsid Database

Feb 10 ，2026

A multitude of AAV capsids have been documented, encompassing widely recognized AAV serotypes (AAV1-13), as well as custom-engineered capsids and naturally occurring capsids isolated from various species such as humans and monkeys. These diverse AAV serotypes offer distinct tropisms tailored for specific cells, both in laboratory settings (in vitro) and within living organisms (in vivo). Generally, AAV serotypes have a primary cellular receptor and sometimes one or multiple coreceptors, which may be present on different cell types and sometimes vary between target species or even strains. To achieve your specific research objectives, it is imperative for researchers to carefully select the optimal AAV capsids that align with the requirements of their projects.

Figure 1. Variant tropisms of AAV serotypes.

  1. Native AAV Serotypes: 
  • AAV1, AAV2, AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAV13.
  1. AAV Isolated from Human:
  • Isolation AAV hu.1, AAV hu.2, AAV hu.3, AAV hu.4…….. AAV hu.67.
  • Isolation hu.T17, hu.T32, hu.T40, hu.T41,Hu.S17, hu.T71, hu.T88.
  1. AAV Isolated from non-human primate:
  • AAVcy.2,AAVcy.3, AAVcy.4, AAVcy.5, AAVcy.6.
  • AAVpi.1, AAVpi.2, AAVpi.3.
  • AAVrh.1, AAVrh.2, AAVrh.8, AAVrh.10, AAVrh.12, AAVrh.13, AAVrh.14, AAVrh.16, AAVrh.17, AAVrh.18, AAVrh.19, AAVrh.22, AAVrh.23, AAVrh.24, AAVrh.32, AAVrh.33, AAVrh.34, AAVrh.35, AAVrh.36, AAVrh.37, AAVrh.38, AAVrh.39, AAVrh.40, AAVrh.43, AAVrh.46, AAVrh.48, AAVrh.49, AAVrh.50, AAVrh.51, AAVrh.52, AAVrh.53, AAVrh.54, AAVrh.55, AAVrh.57, AAVrh.58, AAVrh.60, AAVrh.61, AAVrh.62, AAVrh.64.

4.Engineering AAV capsids

  • Tyrosine (Y) to phenylalanine (F):
    • AAV2: AAV2tYF, AAV2-QuadYF+TV.
    • AAV6: AAV6.2FF, AAV6-TM, AAV6-S663V+T492V, AAV6tYF, AAV6-Y445F.
    • AAV8: AAV8 (dYF+T-V).
    • AAV9: AAV 9.45, AAV 9.61.
    • AAV-LK03-Y705+731F.
  • Tissue specific AAV capsids
    • Muscle: 4D-C102, 2i8G9, AAV 2i8, AAV 4D-C102, AAV-PR, AAVrh32.33, LICA1, eAAV9, AAV.eM, AAVmyo, AAVmyo2, AAVmyo3, myoAAV-1A, myoAAV-2A, myoAAV-3A, myoAAV-4A, AAV587MTP, AAVM41, AAV9.45, AAV9.61.
    • Cardiac: AAV HRH, AAV.KK04, AAV2-THGTPAD, AAV2-NLPGSGD, AAV R484E, R585E,
    • Lung: AAV6.2FF, AAV9.452sub.LUNG1
    • Retina: AAVr2.15, AAV2.7m8, AAVR100, AAV2.GL, AAV2.NN, AAV ShH10, AAV9-IKV, AAV-Rec2, AAVv128, Anc80L65, AAV P2-V1, AAV ShH10Y, AAV2(4pMut)ΔHS, AAV44.9(E531D) , AAV8 BP2 , AAV NHP#9, AAV NHP#26, AAV RC-C02, AAV RC-C14, AAV RC-V25, AAVYC5 , AAV-PT1
    • Liver: AAV DJ, AAV BL154, AAV.GT5, AAV2.MB453, AAV2g9, AAV2-retro, AAV3-ST, AAV-AM, AAV-SYD12, AAV2-K490E, AAV2-K544E, AAV2-K549E, AAV2-K556E, AAV2-LiA,AAV2-LiC, AAV2-MO7A, AAV2-MecA, AAV3B-DE5, AAV3B-DE5, AAV8-1-15, AAV8.N271D, AAV9.N270D, AAV8-Y447+Y733, AAV-DJ-S269T, AAV5-PK2, AAV-LK03-REDH, AAVzk2, AAV XL32.1, AAV MLIV.K, AAV MLIV.A;
    • Crossing blood brain barrier(BBB): Olig001, AAV TR2, AAV2.A1, AAV2.A2, AAV4.18-2, AAV-B1, AAV-BBB6, AAV-BBB28, AAV-BBB31, AAV-BI62, AAV-BI65, AAV-DJ-T251A, AAV-DJ-S503A, AAV-F, AAV-S, AAV-MaCPNS1, AAV-MaCPNS2, AAV-PHP.eC, AAV.v1, AAV-X1, AAV-X1.1, BI-hTFR1, CAP-B10, AAV-BI48, AAV.CPP.21, AAV2-HBKO, AAV9P31, AAV9-Retro, AAV-Se1, AAV-Se2, AAV-DB-3, AAV.S2, AAV1-T593K, AAV variant 5.3, BAP-AAV1, AAV MDV1A, AAV MDV1B, AAV9-PAL2, AAV MV50, AAV  MV53, AAV VCAP-102, AAV Vivec-N002, AAV.CAP-B22, AAV-PHP.V1, AAV.FUS.3, AAV-BI-hTFR1-2/3/4, AAV-M.Fas.1/2/3/4, AAV-PAL1A/B/C/D, AAV PHP.B2/3/4, AAV-Ep+,AAV-M6, AAV-M8, AAV2-LSS, AAV2-PPS, AAV2-TLH, AAV-hCA4-IV77, AAV BRC06, AAV‑PM166
    • T cells: AAV-T1, AAV-T2

 

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