- Capsid Database
The AAV capsid database plays a crucial role in gene therapy and viral vector development. Its core value is reflected in multiple aspects, including providing systematic resources, accelerating vector selection and promoting clinical translation. Below is the characteristic and function of capsid database:
Systematic Integration of AAV Capsid Resources
The AAV capsid database constructs a standardized resource repository by centrally collecting sequence information and functional data of different serotypes, mutants, and engineered capsids. This systematic integration provides researchers with a “one-stop” query platform, avoiding repetitive experiments and significantly enhancing research efficiency.
Accelerating AAV Capsid Selection
The database supports researchers in quickly identifying AAV vectors with specific tissue targeting or immune escape capabilities by providing BLASTp platform and high-throughput screening data. Researchers can selectively choose candidate vectors for validation by analyzing BLASTp results and transduction efficiency of different capsid variants in the liver, muscle, or central nervous system within the database,