Description
pAAV A101
Adeno-associated Viral Vector (AAV) capsid pAAV A101 in AAV2Rep expression construct.
Introduction
AAV A101 developed by 4D molecular therapeutics is a chimera reconstruction from AAV1, AAV2, AAV4, AAV6 and AAV9. It is designed for delivery via nebulization (or aerosolization) to reach all regions of the airways throughout the lungs and to penetrate the mucus barrier for the transduction of lung airway cells. Compared to traditional adeno-associated virus (AAV) vectors, the A101 vector is more advantageous for targeting delivery to human airway cells.
Publication
US 20240067987A1
Sequence information
chimera reconstruction from AAV1, AAV2, AAV4, AAV6 and AAV9
Amino Acid Sequence
MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDQQLKAG
DNPYLKYNHADAEFQQRLQGDTSFGGNLGRAVFQAKKRVLEPLGLVEQAGETAPGKKRPLIESPQQPDSSTGIGKKGKQPAKKRLNFG
QTGDSESVPDPQPLGEPPATPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQ
ISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSD
YQLPYVLGSAHEGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNP
LIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPTGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAM
ASHKDDKDKFFPMSGVMIFGKESAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSSTDPATGDVHAMGALPGMVWQDRD
VYLQGPIWAKIPHTDGHFHPSPLMGGFGLKNPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYT
SNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL*
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pAAV A101
$1,500.00 – $3,000.00
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