Description
pAAV2.7m8
Adeno-associated Viral Vector (AAV) capsid AAV7m8 in AAV2Rep expression construct.
Introduction
AAV variant 7m8 that mediated highly efficient delivery to all retinal layers in mice and nonhuman primates. 7m8 also mediated therapeutic gene delivery to photoreceptors in two mouse models of retinal disease, enabling noninvasive, long-term histological and functional rescue of disease phenotypes across the entire retina.
Publication
DOI: 10.1126/scitranslmed.3005708DOI:
Sequence information
LALGETTRPinsertion at position 588, V708I mutation
Amino Acid Sequence
MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKY
NHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQP
LGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTP
WGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMV
PQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGAS
DIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDE
EEIRTTNPVATEQYGSVSTNLQRGNRLALGETTRPQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQIL
IKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSINVDFTVDTNGVYSEPRPIGTRYLTRNL*
- If you are interested in our products, please click on the ‘Add to WishList’ button below;
- Please send your wishlist for details to info@nikebio.com to get in touch with us；
pAAV2.7m8
$1,500.00 – $3,000.00
Related products
-
pAAVR100
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAV-DB-3
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAV-PHP.eB
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page -
pAAV-KP1
$1,500.00 – $3,000.00 Select options This product has multiple variants. The options may be chosen on the product page
