pAAVAnc80
Adeno-associated Viral Vector (AAV) capsid Anc80 in AAV2Rep expression construct.
Introduction
Anc80L65, a viral-like and AAV-like particle, via structural and biochemical measures and 8.6% or 64 amino acids divergent from the closest known AAV sequence. Anc80L65 furthermore demonstrates high stability, unlike any of the tested extant descendants. Anc80L65 is infectious, and it is efficient as a gene transfer vehicle in murine models for retina, liver, and muscle targeting and in non-human primates for liver-directed gene transfer
Publication
DOI: 10.1016/j.celrep.2015.07.019
Sequence information
Ancestral sequence reconstruction from AAV1-3, AAV6-9
Amino Acid Sequence
MAADGYLPDWLEDNLSEGIREWWDLKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAY
DQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPGKKRPVEQSPQEPDSSSGIGK
KGQQPAKKRLNFGQTGDSESVPDPQPLGEPPAAPSGVGSNTMAAGGGAPMADNNEGADGVGNASGNWHCDSTWLGDR
VITTSTRTWALPTYNNHLYKQISSQSGASTNDNTYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQV
KEVTTNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLR
TGNNFEFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTQTTSGTAGNRTLQFSQAGPSSMANQAKNWLPGPCYRQQ
RVSKTANQNNNSNFAWTGATKYHLNGRDSLVNPGPAMATHKDDEDKFFPMSGVLIFGKQGAGNSNVDLDNVMITSEEEIKT
TNPVATEQYGTVATNLQSSNTAPATGTVNSQGALPGMVWQNRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIK
NTPVPANPPTTFSPAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSTNVDFAVDTNGVYSEPRPIGTRYLTRNL*
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pAAVAnc80
$1,500.00 – $3,000.00
Description
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